Paramyxovirus Glycoproteins and the Membrane Fusion Process
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چکیده
منابع مشابه
Oral 1 STRUCTURE AND ACTIVATION OF PARAMYXOVIRUS FUSION GLYCOPROTEINS
Fusion of the lipid envelope of paramyxoviruses with the host cell plasma membrane during virus entry is mediated by the F protein, a trimeric extracellular transmembrane-anchored glycoprotein. During F-mediated fusion, its fusion peptide inserts into the host cell membrane, followed by large-scale refolding from a largely globular pre-fusion conformation to a golf tee-shaped postfusion conform...
متن کاملCharacterization of the Interaction Between the Attachment and Fusion Glycoproteins Required for Paramyxovirus Fusion: a Dissertation
The first step of viral infection requires the binding of the viral attachment protein to cell surface receptors. Following binding, viruses penetrate the cellular membrane to deliver their genome into the host cell. For enveloped viruses , which have a lipid bilayer that surrounds their nucleocapsids , entry into the host cell requires the fusion of viral and cellular membranes. This process i...
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Herpesvirus entry is a complicated process involving multiple virion glycoproteins and culminating in membrane fusion. Glycoprotein conformation changes are likely to play key roles. Studies of recombinant glycoproteins have revealed some structural features of the virion fusion machinery. However, how the virion glycoproteins change during infection remains unclear. Here using conformation-spe...
متن کاملStructure of the primed paramyxovirus fusion protein.
V iruses with lipid envelopes must fuse their membranes with those of host cells to transfer their genomes and initiate infection. Depending on the virus, the membrane fusion process can occur at the plasma membrane, or at intracellular membranes following the internalization of virus particles. Not surprisingly, the viral proteins responsible for membrane fusion are highly diverse, as are the ...
متن کاملRole of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion.
Paramyxovirus infects cells by initially attaching to a sialic acid-containing cellular receptor and subsequently fusing with the plasma membrane of the cells. Hemagglutinin-neuraminidase (HN) protein, which is responsible for virus attachment, interacts with the fusion protein in a virus type-specific manner to induce efficient membrane fusion. To elucidate the mechanism of HN-promoted membran...
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ژورنال
عنوان ژورنال: Current Clinical Microbiology Reports
سال: 2016
ISSN: 2196-5471
DOI: 10.1007/s40588-016-0040-8